used is lipase from candida rugosa, a fungus.
The enzyme is entrapped in the pores of a hollow fibre membrane
and the ester is delivered in the organic phase to the outside of
The membrane gives a high surface area of
contact between aqueous and organic phases without allowing them
In a second membrane system ibuprofen is extracted into the aqueous
phase at higher pH. The unreacted ester remains in the organic
phase and is recycled.
The half-life of the lipase is about